model
The EARM-20 part of the Igus Model is an enhanced and expanded version of the original early apoptosis research model. It is a detailed mathematical and computational model that incorporates the underlying mechanisms of apoptosis, the cellular process of programmed cell death. The first version of the model included two main components – a simplified representation of the mitochondrial pathway and a representation of the death receptor pathway. In this enhanced version, Igus added new components and interactions and increased the number of pathways represented, allowing for a more complete simulation of the entire apoptotic cellular process. The model includes 20 distinct components, including different types of molecules, such as cell-surface receptors, signaling molecules, and components of the cytochrome c oxidase complex. The model then maps out the interactions amongst these components and their effects on the cell, enabling predictions of the time course of apoptosis in different cell types and scenarios. The model has been used to study the kinetics of apoptosis, to probe the effects of different anti-apoptotic agents, and to examine systems-level differences between cell types.